Zusammenfassung
Tumoren aus dem Bereich der gynäkologischen Onkologie haben in der Regel eine günstige
Prognose, da sie meist in Frühstadien erkannt werden. Dennoch nutzen gynäkologisch-onkologische
Patientinnen, insbesondere Brustkrebspatientinnen, die Möglichkeiten der komplementären
und alternativen Medizin. Derzeit erfolgt diese Behandlung weitgehend ohne einen rationalen
Hintergrund. Inzwischen liegen aber einzelne situationsbezogene und entitätsspezifische
Studien vor, die eine Beratung auf rationaler Ebene ermöglichen. Diese sollten im
Hinblick auf die Wirksamkeit und die Sicherheit stärker berücksichtigt werden.
Summary
Carcinomas from the field of gynaecologic oncology are generally associated with a
favourable prognosis as most of them can be detected quite early. In spite of these
favourable chances many patients, especially breast cancer patients, use the treatment
possibilities of complementary and alternative medicine. However, the current treatment
recommendations mostly are not based on a rational background. Meanwhile there are
several studies which allow a reasonable consultation on the topic. These should be
recognised.
Schlüsselwörter
Gynäkologische Tumoren - Komplementärmedizin (KAM) - Onkologie
Keywords
gynaecologic carcinomas - complementary medicine (CAM) - oncology
Literatur
- 01
Beuth J, Ost B, Pakdaman A, Rethfeld E, Bock P R, Hanisch J, Schneider B.
Impact of complementary oral enzyme application on the postoperative treatment results
of breast cancer patients - results of an epidemiological multicentre retrolective
cohort study.
Cancer Chemother Pharmacol.
2001;
47 Suppl.: S45–54
- 02
Bohm S, Battista Spatti G, Di Re F, Oriana S, Pilotti S, Tedeschi M, Tognella S, Zunino F.
A feasibility study of cisplatin administration with low-volume hydration and glutathione
protection in the treatment of ovarian carcinoma.
Anticancer Res.
1991;
11
1613-1616
- 03
Bardy J, Slevin N J, Mais K L, Molassiotis A.
A systematic review of honey uses and its potential value within oncology care.
J Clin Nurs.
2008;
17
2604-2623
- 04
Chan M M, Soprano K J, Weinstein K, Fong D.
Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer
cells and enhances their cisplatin susceptibility.
J Cell Physiol.
2006;
207
389-396
- 05
Di Re F, Bohm S, Oriana S, Spatti G B, Zunino F.
Efficacy and safety of high-dose cisplatin and cyclophosphamide with glutathione protection
in the treatment of bulky advanced epithelial ovarian cancer.
Cancer Chemother Pharmacol.
1990;
25
355-360
- 06
Duskova M, Wald M.
Orally administered proteases in aesthetic surgery.
Aesthetic Plast Surg.
1999;
23
41-44
- 07
Ernst E, Schmidt K, Baum M.
Complementary/Alternative therapies for the treatment of breast cancer. A systematic
review of randomized clinical trials and a critique of current terminology.
Breast J.
2006;
12
526-530
- 08
Fujitani T.
Influence of proteolytic enzymes on permeation of antibiotics into maxillary sinus
membrane of patients with chronic sinusitis.
Otorhinic Clinic.
1973;
66
557-565
- 09
Frenkel G D, Caffrey P B.
A prevention strategy for circumventing drug resistance in cancer chemotherapy.
Curr Pharm Des.
2001;
7
1595-1614
- 10
García-Closas R, Castellsagué X, Bosch X, González C A.
The role of diet and nutrition in cervical carcinogenesis. a review of recent evidence.
Int J Cancer.
2005;
117
629-637
- 11
Goodwin P J, Ennis M, Pritchard K I, Koo J, Trudeau M E, Hood N.
Diet and breast cancer. evidence that extremes in diet are associated with poor survival.
J Clin Oncol.
2003;
21
2500-2507
- 12
Hernandez-Reif M, Ironson G, Field T, Hurley J, Katz G, Diego M, Weiss S, Fletcher M A,
Schanberg S, Kuhn C, Burman I.
Breast cancer patients have improved immune and neuroendocrine functions following
massage therapy.
J Psychosom Res.
2004;
57
45-52
- 13 Horneber M A, Bueschel G, Huber R, Linde K, Rostock M. Mistletoe therapy in oncology. Cochrane
Database Syst Rev; 2008 (2) CD003297
- 14
Howat R C L, Lewis G D.
The effect of bromelain therapy on episiotomy wounds. A double-blind controlled clinical
trial.
Obstet Gynaecol.
1972;
77
365-368
- 15
Grossarth-Maticek R, Ziegler R.
Prospective controlled cohort studies on long-term therapy of ovairian cancer patients
with mistletoe (Viscum album L.) extracts iscador.
Arzneimittelforschung.
2007;
57(10)
665-78
- 16
Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M,
Arai T et al..
Augmentation by serrapeptase of tissue permeation by cefotiam.
Jpn J Antibiot.
1986;
39
761-771
- 17
Labourey J L.
Physical activity in the management of cancer-related fatigue induced by oncological
treatments.
Ann Readapt Med Phys.
2007;
50
445-454
- 18
Larsson S C, Wolk A.
Tea consumption and ovarian cancer risk in a population-based cohort.
Arch Intern Med.
2005;
165
2683-2686
- 19
Lesperance M L, Olivotto I A, Forde N, Zhao Y, Speers C, Foster H, Tsao M, MacPherson N,
Hoffer A.
Mega-dose vitamins and minerals in the treatment of non-metastatic breast cancer.
an historical cohort study.
Breast Cancer Res Treat.
2002;
76
137-143
- 20
Li Z, Carrier L, Belame A, Thiyagarajah A, Salvo V A, Burow M E, Rowan B G.
Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts
in nude mice through elevated apoptosis and reduced angiogenesis.
Breast Cancer Res Treat.
2008;
118
33-43
- 21
Li Z, Carrier L, Rowan B G.
Methylseleninic acid synergizes with tamoxifen to induce caspase-mediated apoptosis
in breast cancer cells.
Mol Cancer Ther.
2008;
7
3056-3063
- 22
Lissoni P, Tancini G, Paolorossi F, Mandala M, Ardizzoia A, Malugani F, Giani L, Barni S.
Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia
with weekly low-dose epirubicin plus melatonin. a phase II study.
J Pineal Res.
1999;
26
169-173
- 23
Locatelli M C, D'Antona A, Labianca R, Vinci M, Tedeschi M, Carcione R, Corbo A, Venturino P,
Luporini G.
A phase II study of combination chemotherapy in advanced ovarian carcinoma with cisplatin
and cyclophosphamide plus reduced glutathione as potential protective agent against
cisplatin toxicity.
Tumori.
1993;
79
37-39
- 24
Moolenaar M, Poorter R L, van der Toorn P P, Lenderink A W, Poortmans P, Egberts A C.
The effect of honey compared to conventional treatment on healing of radiotherapy-induced
skin toxicity in breast cancer patients.
Acta Oncologica.
2006;
45
623-624
- 25 Münstedt K Hrsg.. Ratgeber unkonventionelle Krebstherapien. 2. Aufl. Landsberg:
Ecomed; 2005
- 26
Nagel G, Hoyer H, Katenkamp D.
Use of complementary and alternative medicine by patients with breast cancer. observations
from a health-care survey.
Support Care Cancer.
2004;
12
789-796
- 27
Nagle C M, Purdie D M, Webb P M, Green A, Harvey P W, Bain C J.
Dietary influences on survival after ovarian cancer.
Int J Cancer.
2003;
106
264-269
- 28
Oh W K, Kantoff P W, Weinberg V, Jones G, Rini B I, Derynck M K, Bok R, Smith M R,
Bubley G J, Rosen R T, DiPaola R S, Small E J.
Prospective, multicenter, randomized phase II trial of the herbal supplement, PC-SPES,
and diethylstilbestrol in patients with androgen-independent prostate cancer.
J Clin Oncol.
2004;
22
3705-3712
- 29
Sartippour M R, Pietras R, Marquez-Garban D C, Chen H W, Heber D, Henning S M, Sartippour G,
Zhang L, Lu M, Weinberg O, Rao J Y, Brooks M N.
The combination of green tea and tamoxifen is effective against breast cancer.
Carcinogenesis.
2006;
27
2424-2433
- 30
Seely D, Oneschuk D.
Interactions of natural health products with biomedical cancer treatments.
Curr Oncol.
2008;
15 Suppl 2:s109.es81–10.es86
- 31
Shah Y M, Al-Dhaheri M, Dong Y, Ip C, Jones F E, Rowan B G.
Selenium disrupts estrogen receptor (alpha) signaling and potentiates tamoxifen antagonism
in endometrial cancer cells and tamoxifen-resistant breast cancer cells.
Mol Cancer Ther.
2005;
4
1239-1249
- 32
Shannon J, Thomas D B, Ray R M, Kestin M, Koetsawang A, Koetsawang S, Chitnarong K,
Kiviat N, Kuypers J.
Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand.
Cancer Causes Control.
2002;
13
691-699
- 33
Sieja K, Talerczyk M.
Selenium as an element in the treatment of ovarian cancer in women receiving chemotherapy.
Gynecol Oncol.
2004;
93
320-327
- 34
Seely D, Mills E J, Wu P, Verma S, Guyatt G H.
The effects of green tea consumption on incidence of breast cancer and recurrence
of breast cancer. a systematic review and meta-analysis.
Integr Cancer Ther.
2005;
4
144-155
- 35
Semiglazov V F.
Quality of life is improved in breast cancer patients by Standardised Mistletoe Extract
PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind,
multicentre clinical trial.
Anticancer Res.
2006;
26
1519-1529
- 36
Shord S S, Shah K, Lukose A.
Drug-botanical interactions. a review of the laboratory, animal, and human data for
8 common botanicals.
Integr Cancer Ther.
2009;
8
208-227
- 37
Smyth J F, Bowman A, Perren T, Wilkinson P, Prescott R J, Quinn K J, Tedeschi M.
Glutathione reduces the toxicity and improves quality of life of women diagnosed with
ovarian cancer treated with cisplatin. results of a double-blind, randomised trial.
Ann Oncol.
1997;
8
569-563
- 38
Vadgama J V, Wu Y, Shen D, Hsia S, Block J.
Effect of selenium in combination with Adriamycin or Taxol on several different cancer
cells.
Anticancer Res.
2000;
20
1391-1414
- 39
Verhoef M J, Balneaves L G, Boon H S, Vroegindewey A.
Reasons for and characteristics associated with complementary and alternative medicine
use among adult cancer patients. a systematic review.
Integr Cancer Ther.
2005;
4
274-286
- 40
Willich S N, Girke M, Hoppe J-D, Kiene H, Klitzsch W, Matthiessen P F, Meister P,
Ollenschläger Günter, Heimpel H.
Schulmedizin und Komplementärmedizin: Verständnis und Zusammenarbeit müssen vertieft
werden.
Dtsch Ärztebl.
2004;
101
A-1314-1319
- 41
van der Zee J, van Rhoon G C.
Cervical cancer. radiotherapy and hyperthermia.
Int J Hyperthermia.
2006;
22
229-234
Korrespondenzadresse
Prof. Dr. med. Karsten Münstedt
Universitätsfrauenklinik Gießen
Klinikstrasse 32
35392 Gießen
Phone: +49 (641) 99 45200
Fax: +49 (641) 99 45139
Email: karsten.muenstedt@gyn.med.uni-giessen.de